Why Intravenous and not oral?
Improving diet and/or oral supplementation are the preferred method to ensure optimal level of nutrition. However there will be occasions when parental (intravenous, intramuscular and subcutaneous) supplementation is needed to bypass the gut absorption and deliver the nutrition directly to the cells . The rationale for choosing parental nutritions depends on many factors:
1. The availability of the specific nutrition in food;
2. The ability of the body to absorb in sufficient quantities;
3. The ability of the body to activate certain vitamins;
4. The occasional need to achieve super-physiological (therapeutic) levels.
For example: vitamin B12, although abundant from animal source foods, can not be absorbed in people with pernicious anaemia and Crohn's disease. Some people may also lack the mechanism to change it to the active form (methylation defects). Another example is vitamin c which is needed in super-physiological doses in certain diseases and infections/post-infections, this can only be achieved by the intravenous route.
Based on the above logic, we hand-picked therapies that require the parental route. Whenever possible, we will administer the therapy as intramuscular or intravenous injection rather than a lengthy drip to reduce time and inconvenience. We will also advice you on oral supplementation when needed.
We provide the following therapies:
Vitamin C therapy (intermediate - high dose: less than 15 gram/dose)
Vitamin C is considered a true all-rounder and thus occupies a special position among micronutrients. The functions and tasks range from collagen building to a pronounced strengthening of our immune system to the protection of lipids, proteins and other cell structures from oxidative damage. Unlike most mammals, the human body cannot produce vitamin C; the sufficient intake of vitamin c from food sources is therefore essential.
There is a debate about the optimal oral daily intake of vitamin C, the standard recommended daily allowance (RDA)is considered minute by some (check this link) and in stressful situations, e.g infections, the need for vitamin C multiplies.
In addition to its function as a powerful anti-oxidant protecting the body from the oxidative stress and the immune system stimulation, vitamin C appears to be important in the syntheses of various hormones and neurotransmitters such as 5-hydroxytryptophan (the precursor of serotonin) thus Influencing mood and a variety of psychological morbidities. Vitamin C also affects the connective tissue by supporting the incorporation of the amino acids lysine and proline into the collagen structures.
Vitamin C megadose therapy (the Riordan protocol)
In addition to the intermediate - high strength vitamin C, we also provide specialist megadoses for specific illnesses.
From 15 g/dose upwards (to achieved a plasma levels of 1000 - 5000 μmol/l), it has been proposed that vitamin C develops a selective cytotoxic effect on cancer cells sparing normal body cells which are able to deal with this effect.
The Riordan intravenous vitamin C protocol involves the slow infusion of massive doses of vitamin C. This is an extremely complex area and involves multiple infusions and testing. Please click on this link to have access to the full Riordan protocol. We also provide a slightly less intensive vitamin c therapy based on the Riordan clinic i.v Vitamin c Push protocol.
Activated Vitamin B12/Folic acid triple injection
Out of about 75 thousand metabolic reactions happening in the human body, only 2 require vitamin B12. However these 2 reactions are extremely important: one reaction occurs in the mitochondria to support the production to ATP (the power molecule) and the other reaction supports the methylation process. These two reactions are extremely important. Methylation is involved in the activation of around 200 enzymes responsible for various functions and DNA repair processes in the body. Therefore vitamin B12 deficiency can cause almost any symptom from neuro-degeneration, including dementia, to blood disorders and fatigue.
Vitamin B12 deficiency is common, this could be the result of poor nutritional intake (e.g. vegans), poor absorption or poor activation.
Low B12 can cause: Fatigue, dizziness, anaemia and other blood count disorders such as low platelets and white cells, nerve damage, neuropathy, tingling in hands and feet, muscle weakness, memory and concentration disorders, depressed moods and dementia.
Measurements of the total vitamin B12 in serum is the most commonly used method to determine the status of B12. However, this test has limitations: even with values in the normal range, an intracellular (inside the cell) or functional B12 deficiency (poor activation of b12) can not be ruled out.
Vitamin B12 can be administered by intravenous, intramuscular or subcutaneous administration. Hydroxocobalamin is the most commonly used form of vitamin B12 (This is the B12 you can get from your GP if you have severe deficiencies or if you can not absorb the oral form). At Leicester Ozone Clinic we use the activated forms of vitamin B12: Methylcobalamin and Adenosylcobalamin. This is because some people lack the enzymatic process needed to convert the inactive Hydroxocobalamin to the active forms Methylcobalamin and Adenosylcobalamin.
Adenosylcobalamin works in the mitochondria, which is responsible for the energy production inside the cells. The final outcome is the production of "ATP", which is the energy currency in the body. This is one of the reason why B12 deficiency can cause fatigue. Methylcobalamin is also involved in enzymatic processes such as synthesis of various amino acids and the covering of nerves. Because of the slightly different role of Methylcobalamin and Adenosylcobalamin, at LOC we advocate the use of both of these activated forms at the same time AND to have folic acid as well as B12 due to the close relationship of metabolism.
Folate (or folic acid) is a form of B vitamin (B9) that occurs naturally in many foods. Folic acid is essential to the development of the central nervous system. Insufficient folate activity at the time of conception and early pregnancy can result in congenital neural tube defects hence pregnant ladies are regularly given folic acid. Folic acid is the man-made form of folate. A lack of folate can be caused by certain diseases, by taking certain medications, or by not getting enough folate in the diet. Folate deficiency can lead to anaemia, neurological and psychiatric problems and can also cause high levels of a certain amino acid in the blood called Homocystein, which causes cardiovascular problems.
Some people lack the ability to activate (methylate)folate as a results of a gene defect called the "MTHFR gene".
The metabolism of B12 (in its 2 active forms)is closely linked to that of folate. It is well known that replacing one only may result in an acute deficiency of the other, which may lead to a neurological crisis. We therefore advice to administer them in a triple injection at the same time.
The ATP Concentrate
The "ATP concentrate" is a revitalising and energising infusion. It is a ready made combination of various vitamins, amino acids and minerals. It may be more suitable for people with poor diet or special diety requirements but with no specific deficiency in absorption or activation. This infusion includes:
L-Arginin 500 mg
Glycin 250 mg
Taurin 250 mg
Magnesium-DL-hydrogenaspartat 125 mg
Riboflavin-5-Phosphat 2.5 mg
Nicotinamid 25 mg
D-Panthenol 25 mg
Pyridoxin-HCl 25 mg
Adenosylcobalamin 0.25 mg
L-Lysin 250 mg
N-Acetyl-L-Tyrosin 125 mg
Kalium-DL-hydrogenaspartat Hemihydrat 125 mg
Hydroxocobalamin 0.25 mg
Methylcobalamin 1.25 mg
The ATP concentrate is administered as a 250 ml infusion over 15-30 minutes.