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Can vitamin c and ozone be given together?

The question of whether it's appropriate to simultaneously administer high-dose vitamin C and ozone therapy is a common one. A cursory internet search suggests that this combination might not be advisable. This perception is rooted in the simplistic notion held by some that vitamin C is an "antioxidant," while ozone is a "pro-oxidant," leading to the belief that they counteract each other. Some laboratory research on blood products has been conducted to support this viewpoint. However, like most matters, a deeper understanding of the intricacies can shed light on the possibility and even desirability of employing both potent therapies together.


It's crucial to note, before delving further into this discussion, that there are NO human studies supporting the idea that vitamin C and ozone neutralize each other when administered concurrently through standard methods. The following discussion is, therefore, grounded in a comprehensive comprehension of the mechanisms underlying each therapy, with an aim to form an opinion on their co-administration.


Certainly, ozone is an oxidant, and vitamin C is an antioxidant, which logically suggests they may cancel each other out when administered simultaneously. Nevertheless, vitamin C, when administered in higher doses (e.g. over 25 grams intravenously), undergoes a shift from its antioxidant role to acting as a pro-oxidant. By applying this logic, it becomes plausible to combine high-dose vitamin C with ozone because they are now functioning in a synergistic manner. It's essential to clarify that this is not a recommendation, but rather a demonstration that this approach could be considered feasible or even desirable.


In reality, ozone undergoes a transformation when it interacts with the bloodstream or tissues. Studies have confirmed that ozone promptly interacts with blood cells upon entering the circulatory system during major autohemotherapy. In simpler terms, ozone vanishes from circulation within a few minutes of administration, leaving behind only the byproducts of this interaction, collectively referred to as "ozonides," which produce the beneficial effects associated with ozone. This crucial point is strongly emphasized in the latest guidelines from the German Ozone Society, as illustrated in the provided screenshot:



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Unlike ozone, high-dose vitamin C remains present in the bloodstream for extended periods following infusion, with the duration dependent on the dosage. The following extract from the Riordan Clinic High Dose Vitamin C Protocol highlight this fact:



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Drawing from the earlier explanation, it is possible to combine ozone and vitamin C in a single therapy session, but ozone should be administered initially, followed by vitamin C, with a brief interval in between. This interval, which might only require a few minutes, ensures complete utilization of ozone before commencing with vitamin C. Research has indicated that this approach yields more favorable results when compared to administering these therapies individually, especially within the context of cancer treatment. Click this link to access the original article from The Journal of Ozone Therapy confirming that the researchers used "simultaneous high dose of Vitamin C [and] Major Auto Haemo Therapy (MAHT) for more than hundreds of cases with much better results". The authors of another paper (check this link) recommend the administration of both therapies for better effect in the context of cancer therapy using the above mentioned sequence with a generous gap of 30 minutes. This is the important extract from this paper:





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At Leicester Ozone Clinic, we firmly advocate for the simultaneous administration of vitamin C and ozone therapy. Our preferred procedure involves the administration of ozone initially, followed by vitamin C. We conducted bedside blood tests at the conclusion of the infusion on many occasions and we are satisfied that high levels of vitamin c are achieved after ozone therapy. Also, remarkable clinical outcomes have been consistently observed with this combined approach. Additionally, the use of the ozonated saline method, also known as the Russian method, is particularly suitable due to its requirement for a minimal amount of ozone infused over longer periods of time, which minimizes the likelihood of interaction with vitamin C or other antioxidants.





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