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Neural Infusion Therapy: Procaine-Base Infusion






Procain is a “veteran” drug currently used as a local anaesthetic. It was discovered in 1905 by Alfred Einhorn. As early as 1892, the German chemist began to model on the structural formula of cocaine, the first known local anesthetic, in order to obtain less addictive molecules, but with similar or enhanced anesthetic qualities. Thus, he synthesized procaine—the first injectable anesthetic, introduced in medical practice under the trade name of Novocaine, which means “new cocaine.


Despite being in use for over a decade, Procaine continues to incite interest, revealing new biological and pharmacological effects beyond its anesthetic actions. Due to its short-term anesthetic effect and need for repeated administration to achieve longer anesthesia, observations regarding the interesting changes occurring following prolonged use started to emerge in the medical community.


Clinicians noticed “rejuvenating” effects in elderly patients: memory enhancement, alleviation of depression, hair repigmentation, better skin tone, and an overall improvement of their condition. All these observations resulted, at that stage, in regarding procaine as “a useful prophylactic and therapeutic substance in the fight against old age” as a result of procaine’s effect on oxidative stress, inflammation, atherogenesis, cerebral age-related pathology, DNA damage, and methylation.


Procain’s effect on mental health has also been observed. long-term relaxing, anti-depressive and anxiolytic effects are often observed when infusions of Procaine are given. This may in part be related to its blood vessels dilating effect and its effect on cell membranes, including neural cell membranes. Procain increases blood flow to areas in the brain concerned with emotions. Several scientists have also reported procaine’s activity on many biochemical systems such as dopamine, norepinephrine, serotonin, glutamate, among others. Furthermore, more recent data revealed that procaine modulate monoamine oxidase (MAO) activity, which may partially explain its effect on mental health.


At leicester Ozone clinic we start with a dosage of 50-100 mg Procaine-HCl and 20 ml sodium hydrogen carbonate (8.4%) as a "Base" diluted in a 250 to 500 ml carrier solution. The infusion takes place for approximately 45-60 minutes. By adding increments of 50 mg Procaine-HCl and 10 ml sodium bicarbonate (8.4%), the Procaine infusion will be titrated until the desired therapeutic effect is reached. For a normal-weight person the maximal dosage of Procaine-HCl is 300 mg. It is advised to avoid driving for about one hour after treatment.


Without any prior acid-base diagnostic, the procaine-base infusion should not be administered more than three times per week with a minimum of one day break between treatment days. A series of 6 to 10 infusions are advised.


Possible areas of application: Procain infusions can be used in chronic inflammatory conditions, autoimmune conditions, chronic pain, migraine, chronic fatigue, degenerative brain conditions such as Parkinson’s disease and dementia or for general rejuvenation.

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