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The use of ozone in therapy

What is medical-grade ozone? Ozone gas (O3) is the oxygen (O2) we breathe with an extra atom added. Ozone is unstable; it rapidly degenerates back to oxygen hence it needs to be prepared on site and administered quickly mixed with oxygen (95%-99.95% oxygen and 0.05%-5% ozone).


Which countries regulate ozone therapy? 

The medical use of ozone was pioneered by German scientists in the sixties. Before the advent of antibiotics, ozone was the main antimicrobial therapy and had been used in world wars to sterilise infected wounds. According to the International Scientific Committee of Ozone Therapy (Madrid Declaration on Ozone Therapy; 3rd edition; as of 2020, ozone therapy has been regulated by the state in 13 countries. Some of these countries, e.g Spain and Brazil, have ozone therapy offered in the public health facilities.

How does ozone work? Ozone does not work directly; it instantaneously interacts with components of the cells to form secondary chemical compounds known collectively as "ozonides". It is those "secondary messengers" that exert the biological effects seen with ozone therapy. The effect of ozone is related to 3 main actions:

  • Ozone is thought to increase the body's antioxidant capacity;

  • Ozone is thought to boost the immune system;

  • Ozone is thought to increase a specific enzyme in red blood cells called 2,3-diphosphoglycerate (2,3-DPG) thus allowing the red cells to release more oxygen to tissues.

What conditions can be helped by ozone? Ozone has been used in a variety of conditions involving "oxidative stress" or faultily immune system such as cardiovascular diseases, autoimmune diseases, infections, neurological conditions, chronic fatigue, brain fog or simply to boost energy and rejuvenate.

How is ozone administered?

  • Auto-haemotherapy (WATCH): This is the most popular method in Europe where a small amount of blood is extracted then mixed with ozone/oxygen gas and an anticoagulant before injecting the blood back. This process is known as "Major Auto-haemotherapy". The process can be repeated multiple times; each time is called a "pass" hence the terms "5 passes" or "10 passes". 

  • Ozonized Saline infusion (WATCH): This is the most researched form of ozone therapy. It does not require anticoagulants and does not involve taking blood outside the body thus making it a safer technique. The following is an extract from the International Scientific Committee of Ozone Therapy (Madrid Declaration on Ozone Therapy; 3rd edition;



  • ​​​Insufflation: This method involves injecting ozone in to a body cavity, such as the colon (rectal insufflation).

  • Joint and soft tissue injection: Ozone may be injected directly in to a joint or in to a trigger point.

  • Topical skin applications: ozone can can be delivered externally to a specific area of the body.

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how often do i need ozone?

The number of ozone sessions and the ozone dosage administered will depend on the general condition, the sensitivity of the tissues to the effects of ozone and the condition being targeted. As a general rule, it is given in cycles that vary between 5 to 20 sessions, usually 1 -3 times a week.

side effects of ozone

As with any blood-letting procedure or injection, cannula-related complications such as bruising is expected. Some people feel flu-like symptoms after each session, these side effects are transient and should be followed by the desired effect. When ozone is administered by rectal insufflation, it can cause bloating and constipation.